Concept: The head of government is the person who runs the government, distinct from the ceremonial head of state.Explanation:During Ghana's Second Republic (1969–1972), the political system made the President the Head of State and the Prime Minister the Head of Government.Dr. Kofi Abrefa Busia served as the Prime Minister, meaning he was the Head of Government.Therefore, the head of government of the Second Republic was the Prime Minister.Answer: Prime Minister