Concept:Biotechnology uses living organisms or their biological processes to create useful products.Explanation:Baking of bread involves yeast, which is a living organism used for fermentation.Production of wine also uses yeast to convert sugars into alcohol.Production of antibiotics relies on microorganisms such as fungi and bacteria.Manufacturing of soap is based on the chemical process of saponification, which does not involve any living organism.Since soap making does not use biological agents, it is not an application of biotechnology.Answer:D. manufacturing of soap